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49ers vs Eagles Prediction 1/11/26 NFL Picks Today

San Francisco 49ers (12-5) vs. Philadelphia Eagles (11-6)
January 11, 2026 4:30 pm EDT
The Line: Philadelphia Eagles -4.5; Over/Under: 44.5
(Get latest betting odds)

In this article, we will formulate a 49ers vs Eagles Prediction for this NFC Wild Card game on Sunday, January 11th. Let’s take a look at the prediction for this NFL matchup.

Philadelphia Eagles Preview

The Philadelphia Eagles have a 11-6 record this season and finished first in the NFC East. They are 10-7 ATS, 7-10 in Over/Under and have a 5-3 home record and a 6-3 away record. The Eagles are coming off a 17-24 home loss against the Washington Commanders.

Offensively, the Eagles average 22.3 points per game, ranking 19th in the NFL, while defensively, they allow 19.1 points per game, which is 5th. Philadelphia averages 311.2 total yards per game (194.3 passing and 116.9 rushing), while allowing 314.2 total yards per game (124.4 rushing and 189.8 passing).

Jalen Hurts leads the Eagles with 3224 passing yards with 64.8% completed passes and 25 touchdowns. Saquon Barkley leads the team in rushing yards with 1140, while A.J. Brown has a team-high 78 receptions for 1003 receiving yards, and seven touchdowns. Defensively, Zack Baun has a team-high 123 total tackles (64 of them solo), while Jalyx Hunt leads the team in sacks, with 6.5, while Jalyx Hunt has 3 interceptions.

San Francisco 49ers Preview

The San Francisco 49ers have a 12-5 record this season and finished second in the NFC West. They are 11-6 ATS, 10-6 in Over/Under and have a 7-2 home record and a 5-3 away record. The 49ers are coming off a 3-13 home loss against the Seattle Seahawks.

Offensively, the 49ers average 25.7 points per game, ranking 10th in the NFL, while defensively, they allow 21.8 points per game, which is 13th. San Francisco averages 351.4 total yards per game (244.5 passing and 106.9 rushing), while allowing 340.2 total yards per game (107.8 rushing and 232.4 passing).

Brock Purdy leads the 49ers with 2167 passing yards with 69.4% completed passes and 20 touchdowns. Christian McCaffrey leads the team in rushing yards with 1202, while Christian McCaffrey has a team-high 102 receptions for 924 receiving yards, and seven touchdowns. Defensively, Dee Winters has a team-high 101 total tackles (67 of them solo), while Clelin Ferrell leads the team in sacks, with 4, while Ji’Ayir Brown and Deommodore Lenoir have two interceptions each.

San Francisco 49ers @ Philadelphia Eagles Betting Trends: Wild Card Round

 

Why the Philadelphia Eagles will win

  • The Eagles have won each of their last nine Sunday games against teams that held a winning record.
  • The 49ers have lost each of their last five games without Kendrick Bourne.
  • The Eagles have covered the spread in each of their last seven Sunday games against teams that held a winning record.
  • The 49ers have failed to cover the spread in 12 of their last 13 Sunday games against teams that held a winning record.
  • The Eagles have scored the first touchdown in 19 of their last 20 Sunday games.
  • The favorites have won the first half in each of the 49ers’ last 10 games.
  • The Eagles have won the first quarter in 10 of their last 11 Sunday games against teams that held a winning record.

Why the San Francisco 49ers will win

  • The 49ers have won each of their last six games against NFC East opponents.
  • The Eagles have lost each of their last three games as favorites without Tanner McKee.
  • The 49ers have covered the spread in each of their last six games against NFC East opponents.
  • The Eagles have failed to cover the spread in each of their last six games as home favorites following a home loss.
  • The Eagles have lost the first quarter in each of their last three games as favorites following a home loss.
  • The 49ers have scored the first touchdown in four of their last five games following a loss.
  • The road team has won the first half in each of the 49ers’ last six Wild Card Round games.

Total Points Facts

  • Each of the 49ers’ last seven road postseason games against NFC opponents have gone UNDER the total points line.
  • Each of the Eagles’ last six games without Tanner McKee have gone UNDER the total points line.

Philadelphia Eagles Player Prop Facts

  • A.J. Brown has scored the last touchdown in three of the Eagles’ last four games following a loss.
  • Saquon Barkley has scored two touchdowns in three of his last four appearances with his team as a favorite against NFC West opponents.
  • Jalen Hurts has scored at least one touchdown in 10 of the Eagles’ last 12 games at Lincoln Financial Field against teams that held a winning record.
  • Jalen Hurts has recorded 21+ completions in each of the Eagles’ last three games following a home loss.
  • Jalen Hurts has recorded 39+ rushing yards in seven of the Eagles’ last eight games as favorites against NFC West opponents.
  • Jahan Dotson has recorded 12+ receiving yards in each of the Eagles’ last four home games against NFC opponents.
  • Jalen Hurts has recorded 230+ passing yards in eight of his last nine appearances following a loss.
  • Tank Bigsby has recorded 34+ rushing and receiving yards in each of the Eagles’ last four Sunday home games.
  • Heading into the Wild Card Round, Jalen Hurts has the highest passer rating in a single game (min. 10 ATT) this season (158.3 vs Vikings, Week 7).

San Francisco 49ers Player Prop Facts

  • Christian McCaffrey has scored two or more touchdowns in each of the 49ers’ last three games following a loss.
  • Brock Purdy has recorded 23+ completions in three of the 49ers’ last four games.
  • Brock Purdy has recorded 230+ passing yards in eight of his last nine road appearances against NFC opponents.
  • George Kittle has recorded 67+ receiving yards in each of his last four Sunday appearances.
  • Brian Robinson has recorded 24+ rushing yards in each of his eight previous appearances with his team as an underdog against NFC East opponents.
  • Christian McCaffrey has scored at least one touchdown in each of his seven previous postseason appearances.
  • Brian Robinson has recorded 36+ rushing and receiving yards in each of his six previous appearances against the Eagles.
  • Heading into the Wild Card Round, Brock Purdy has recorded the equal-most passing touchdowns in a single game this season (5 vs Colts, Week 16).

Matchup/League Facts

  • Eagles – two different players have recorded 80+ rushing yards in a game this season – equal-most in the NFL, heading into the Wild Card Round.
  • Eagles – two different players have recorded 90+ rushing yards in a game this season – equal-most in the NFL, heading into the Wild Card Round.
  • The 49ers ranked 32nd in the NFL in sacks (20.0) during the reg. season.
  • The 49ers ranked 32nd in the NFL in total punt yards (1919) during the reg. season.

49ers vs Eagles Prediction

In this 49ers vs Eagles Prediction, the Eagles are coming as -4.5-point home favorites. Both teams have almost identical overall records this season but the 49ers have been a much better road team and are 6-1 in their last 7 games and 5-2 against the spread. On the flip side, the Eagles are 3-4 in their last 7 games and 3-4 against the spread and have a weaker offense than the 49ers, so I think that they are being overvalued in this spot. The 49ers are also 3-2 in their last 5 visits in Philly and I expect them to keep this one close. Take the 49ers and get the +4.5 points in this one.

 

Nikos Lagouretos's Free Pick: San Francisco 49ers +4.5

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