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Arizona Cardinals vs Detroit Lions Prediction 9-22-24 NFL Picks

Detroit Lions (1-1) vs. Arizona Cardinals (1-1)
September 22, 2024 4:25 pm EDT
The Line: Arizona Cardinals +3; Over/Under: 52
(Get latest betting odds)

The Detroit Lions and Arizona Cardinals meet Sunday in week 3 NFL action at State Farm Stadium. Here’s an Arizona Cardinals vs Detroit Lions Prediction. This article will include an Arizona Cardinals vs Detroit Lions Pick.

Detroit Lions Betting Preview

The Detroit Lions beat the Rams, lost to the Buccaneers, and play the Seahawks next. The Detroit Lions have won 6 of their last 9 road games. Jared Goff is completing 62.7 percent of his passes for 524 yards, 1 touchdown, and 3 interceptions. Jameson Williams and Amon-Ra St. Brown have combined for 332 receiving yards and 1 touchdown, while Sam LaPorta has 6 receptions.

The Detroit Lions ground game is averaging 151 yards per contest, and David Montgomery leads the way with 126 yards and 2 touchdowns. Defensively, Detroit is allowing 20 points and 301.5 yards per game. Alex Anzalone leads the Detroit Lions with 17 tackles, Aidan Hutchinson has 5.5 sacks and Kerby Joseph has 1 interception.

Arizona Cardinals Betting Preview

The Arizona Cardinals lost to the Bills, beat the Rams, and play the Commanders next. The Arizona Cardinals have lost 5 of their last 7 home games. Kyler Murray is completing 73.1 percent of his passes for 428 yards, 4 touchdowns, and 0 interceptions. Marvin Harrison Jr. and Trey McBride have combined for 231 receiving yards and 2 touchdowns, while Greg Dortch has 8 receptions.

The Arizona Cardinals ground game is averaging 177.5 yards per contest, and James Conner leads the way with 172 yards and 2 touchdowns. Defensively, Arizona is allowing 22 points and 298.5 yards per game. Budda Baker leads the Arizona Cardinals with 18 tackles, Dennis Gardeck has 3 sacks and Mack Wilson Sr. has 1 pass deflection.

Why the Arizona Cardinals will win

  • The Lions have lost 21 of their last 24 road games against NFC West opponents.
  • The underdogs have won each of the last two games between the Lions and Cardinals.
  • The Cardinals have covered the spread in each of their last five games in September.
  • The Lions have failed to cover the spread in four of their last five games as favorites against NFC West opponents.
  • The underdogs have won the first quarter in each of the Lions’ last three games.
  • The Cardinals have scored the first touchdown in six of their last seven Week 3 games.
  • The Cardinals have won the first half in each of their last five games in September.

Arizona Cardinals Player Prop Facts

  • Kyler Murray has recorded 33+ rushing yards in eight of his last nine appearances following a win.
  • Kyler Murray has recorded 230+ passing yards in each of his last seven September appearances against NFC opponents.
  • Elijah Higgins has recorded 12+ receiving yards in each of the Cardinals’ last eight games.
  • James Conner has recorded 83+ rushing and receiving yards in each of the Cardinals’ last seven Sunday games.
  • James Conner has scored at least one touchdown in each of the Cardinals’ last seven games.
  • Kyler Murray has thrown two or more touchdowns in four of his last five home appearances in September.
  • Kyler Murray has recorded 23+ completions in each of his four previous Week 3 appearances.
  • Marvin Harrison Jr. ranks T1st in the NFL in receiving touchdowns (2) this season.

Detroit Lions Player Prop Facts

  • David Montgomery has scored a touchdown in eight of the Lions’ last nine regular season games against NFC opponents.
  • Jahmyr Gibbs has recorded 60+ rushing yards in each of the Lions’ last five Sunday regular season road games.
  • Jared Goff has recorded 271+ passing yards in six of the Lions’ last seven games.
  • David Montgomery has recorded 10+ receiving yards in each of his five previous road appearances against NFC West opponents.
  • David Montgomery has recorded 67+ rushing and receiving yards in each of his last seven September appearances with his team as a favorite against NFC opponents.
  • Jared Goff has thrown three or more touchdowns in three of his last four regular-season appearances against NFC West opponents.
  • Jared Goff has recorded 25+ completions in three of the Lions’ last four games.
  • Aidan Hutchinson ranks 1st in the NFL in sacks (5.5) this season.

Matchup/League Facts

  • The Cardinals rank T1st in the NFL in fumbles recovered (2) this season.
  • The Cardinals are the only team in the NFL to rank top 5 for both sacks and fumbles recovered this season.
  • The Lions rank 2nd in the NFL in yards per game (413.0) this season.
  • The Lions rank 2nd in the NFL in passing yards per game (262.0) this season.

Arizona Cardinals vs Detroit Lions Prediction

The Detroit Lions are going to be favored based on their reputation and the way many viewed them entering the season. However, the Lions looked sloppy last week against the Bucs, and we can’t ignore they were taken to overtime by an injured Rams squad. The same Rams team the Cardinals just took behind the woodshed. The Lions could easily be winless with an offense that’s not finishing drives and a defense that’s getting torched through the air. We also can’t ignore that the Cardinals had the Bills beat on the road. It’s only two games, but the Cardinals are showing legit potential.

With the second-best scoring offense and a defense that can stop the run, I’m keeping an eye on the Cardinals these next few weeks. Give me my free field goal with the Cards.

Randy Chambers's Free Pick: Arizona Cardinals +3

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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