Arizona Cardinals vs San Francisco 49ers Prediction 1-5-25 NFL Picks

San Francisco 49ers (6-10) vs. Arizona Cardinals (7-9)
January 5, 2025 4:25 pm EDT
The Line: Arizona Cardinals +1; Over/Under: +46.5
(Get latest betting odds)

The San Francisco 49ers and Arizona Cardinals meet Sunday in week 18 NFL action at State Farm Stadium. Here’s an Arizona Cardinals vs San Francisco 49ers Prediction. This article will include an Arizona Cardinals vs San Francisco 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers are coming off losses to the Rams, Dolphins, and Lions. The San Francisco 49ers have lost 3 straight road games. Brock Purdy is completing 65.9 percent of his passes for 3,864 yards, 20 touchdowns, and 12 interceptions. George Kittle and Jauan Jennings have combined for 2,002 receiving yards and 14 touchdowns, while Deebo Samuel Sr. has 51 receptions.

The San Francisco 49ers ground game is averaging 126.6 yards per contest, and Jordan Mason leads the way with 789 yards and 3 touchdowns. Defensively, San Francisco is allowing 24.3 points and 312.7 yards per game. Fred Warner leads the San Francisco 49ers with 123 tackles, Nick Bosa has 9 sacks and Deommodore Lenoir has 2 interceptions.

Arizona Cardinals Betting Preview

The Arizona Cardinals recently beat the Patriots, while losing to the Panthers and Rams. The Arizona Cardinals have won 4 of their last 5 home games. Kyler Murray is completing 68.6 percent of his passes for 3,609 yards, 17 touchdowns, and 11 interceptions. Trey McBride and Marvin Harrison Jr. have combined for 1,903 receiving yards and 8 touchdowns, while Michael Wilson has 47 receptions.

The Arizona Cardinals ground game is averaging 143.8 yards per contest, and James Conner leads the way with 1,094 yards and 8 touchdowns. Defensively, Arizona is allowing 22.2 points and 336.7 yards per game. Budda Baker leads the Arizona Cardinals with 155 tackles, Dante Stills has 4.5 sacks and Garrett Williams has 2 interceptions.

Arizona Cardinals vs San Francisco 49ers Injury Report

The big injury news for the 49ers is quarterback Brock Purdy being doubtful with an elbow injury. That means Joshua Dobbs likely gets the start, and he’d get a shot at a Cardinals team he started 8 games for last season. There are a lot of injuries on defense as well for the 49ers. Charvarius Ward, Leonard Floyd, and Demetrius Flannigan-Fowles are questionable, while Dre Greenlaw has been shut down for the season.

For the Cardinals, running back Trey Benson and safety Joey Blunt have been placed on injured reserve. Star running back James Conner is also questionable after leaving last week with a knee injury. With the running back depth so banged up, Michael Carter could see a lot of playing time.

Why the Arizona Cardinals will win

The 49ers have lost eight of their last nine Sunday games at State Farm Stadium.
The home team has won seven of the Cardinals’ last eight games.
The 49ers have failed to cover the spread in seven of their last eight games.
The Cardinals have covered the spread in five of their last six games following a road loss.
The home team has won the first quarter in each of the 49ers’ last seven games.
The Cardinals have scored the first touchdown in each of their last seven Sunday games as home favorites.
The 49ers have lost the first half in each of their last six games as road underdogs following a home loss.

Arizona Cardinals Player Prop Facts

James Conner has scored at least one touchdown in each of the Cardinals’ last six day games against teams with a losing record.
Trey Benson has recorded 15+ rushing yards in each of his last six appearances.
Kyler Murray has recorded 232+ passing yards in seven of the Cardinals’ last eight games following a road loss.
James Conner has recorded 113+ rushing and receiving yards in each of the Cardinals’ last six home games.
Elijah Higgins has recorded 11+ receiving yards in seven of the Cardinals’ last eight home games against NFC opponents.
Kyler Murray has recorded 22+ completions in 10 of his last 11 home appearances against NFC West opponents.
Jalen Thompson is just one away from 10 career interceptions.

San Francisco 49ers Player Prop Facts

Russell Gage has scored the last touchdown in three of his last four Sunday appearances with his team as an underdog.
Deebo Samuel has recorded 58+ receiving yards in each of his last six appearances with the 49ers as underdogs against NFC West opponents.
Joshua Dobbs has scored a touchdown in each of his last six appearances with his team as an underdog.
Deebo Samuel has recorded 13+ rushing yards in each of his last five appearances with the 49ers as underdogs on the West Coast.
Brock Purdy has recorded 292+ passing yards in four of his last five Sunday road appearances.
Deebo Samuel has recorded 71+ rushing and receiving yards in each of his last five appearances with the 49ers as underdogs against NFC West opponents.
Brock Purdy has recorded 22+ completions in five of his last six Sunday regular season road appearances.
Heading into Week 18, Jauan Jennings has recorded the equal-most receiving touchdowns in a single game this season (3 vs Rams, Week 3).

Matchup/League Facts

Heading into Week 18, the Cardinals rank 30th in the NFL in 4th down percentage (37.5%) this season.
Heading into Week 18, the Cardinals rank T3rd in the NFL in H2 win percentage (68.8) this season.
Heading into Week 18, the 49ers rank 32nd in the NFL in total punt yards (1976) this season.
Heading into Week 18, the 49ers rank 32nd in the NFL in H2 opponent points per game (15.4) this season.