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Miami Dolphins vs San Francisco 49ers Prediction 12-22-24 NFL Picks

San Francisco 49ers (6-8) vs. Miami Dolphins (6-8)
December 22, 2024 4:25 pm EDT
The Line: Miami Dolphins -1; Over/Under: +50
(Get latest betting odds)

The San Francisco 49ers and Miami Dolphins meet Sunday in week 16 NFL action at Hard Rock Stadium. Here’s a Miami Dolphins vs San Francisco 49ers Prediction. This article will include a Miami Dolphins vs San Francisco 49ers Pick.

San Francisco 49ers Betting Preview

The San Francisco 49ers lost to the Rams, beat the Bears, and play the Lions next. The San Francisco 49ers have lost 4 of their last 6 road games. Brock Purdy is completing 65 percent of his passes for 3,174 yards, 15 touchdowns, and 9 interceptions. George Kittle and Jauan Jennings have combined for 1,666 receiving yards and 14 touchdowns, while Deebo Samuel Sr. has 43 receptions.



The San Francisco 49ers ground game is averaging 133.5 yards per contest, and Jordan Mason leads the way with 789 yards and 3 touchdowns. Defensively, San Francisco is allowing 22.9 points and 298.8 yards per game. Fred Warner leads the San Francisco 49ers with 106 tackles, Leonard Floyd has 8.5 sacks and Deommodore Lenoir has 2 interceptions.

Miami Dolphins Betting Preview

The Miami Dolphins beat the Jets, lost to the Texans, and they play the Browns next. The Dolphins have won 3 straight home games. Tua Tagovailoa is completing 73.7 percent of his passes for 2,652 yards, 18 touchdowns, and 7 interceptions. Tyreek Hill and Jonnu Smith have combined for 1,545 receiving yards and 11 touchdowns, while Jaylen Waddle has 54 receptions.

The Miami Dolphins ground game is averaging 101.4 yards per contest, and De’Von Achane leads the way with 641 yards and 4 touchdowns. Defensively, Miami is allowing 22.3 points and 308.6 yards per game. Jordyn Brooks leads the Miami Dolphins with 121 tackles, Zach Sieler has 7.5 sacks and Jalen Ramsey has 2 interceptions.

Why the Miami Dolphins will win

  • The home team has won each of the Dolphins’ last five games.
  • The 49ers have lost five of their last six Week 16 games against AFC opponents.
  • The Dolphins have covered the spread in 12 of their last 14 Sunday games against teams that held a losing record.
  • The 49ers have failed to cover the spread in five of their last six games.
  • The Dolphins have scored the first touchdown in each of their last five games played on the East Coast.
  • The Dolphins have won the first half in each of their last seven games as favorites against NFC opponents.
  • The favorites have won the first quarter in each of the 49ers’ last 12 games.

Miami Dolphins Player Prop Facts

  • Jonnu Smith has scored the last touchdown in three of the Dolphins’ last four Sunday games.
  • De’Von Achane has scored at least one touchdown in each of the Dolphins’ last six Sunday home games.
  • Tyreek Hill has recorded 77+ receiving yards in eight of his last nine appearances with his team as a favorite against NFC opponents.
  • Raheem Mostert has recorded 19+ rushing yards in each of his last 18 appearances with his team as a favorite against NFC opponents.
  • Tua Tagovailoa has recorded 280+ passing yards in each of the Dolphins’ last four December games against NFC opponents.
  • Raheem Mostert has recorded 21+ rushing and receiving yards in each of his last 17 December appearances.
  • Tua Tagovailoa has thrown two or more touchdowns in each of the Dolphins’ last four games played on the East Coast.
  • Tua Tagovailoa has recorded 25+ completions in each of the Dolphins’ last six Sunday games.
  • Heading into Week 16, De’Von Achane is one of only two players in the NFL to record 500 rushing yards and 500 receiving yards this season.

San Francisco 49ers Player Prop Facts

  • George Kittle has scored at least one touchdown in seven of the 49ers’ last eight games following a home loss.
  • Brock Purdy has recorded 292+ passing yards in three of his last four Sunday road appearances.
  • Deebo Samuel has recorded 76+ rushing and receiving yards in three of the 49ers’ last four games in Florida.
  • Deebo Samuel has recorded 20+ rushing yards in seven of his nine previous December road appearances.
  • Russell Gage has scored the last touchdown in three of his last four Sunday appearances with his team as an underdog.
  • George Kittle has recorded 74+ receiving yards in five of the 49ers’ last six Week 16 games.
  • Brock Purdy has recorded 22+ completions in four of his last five Sunday regular season road appearances.
  • Brock Purdy has thrown two or more touchdowns in four of the 49ers’ last five road games in December.
  • Heading into Week 16, Jauan Jennings has recorded the equal-most receiving touchdowns in a single game this season (3 vs Rams, Week 3).

Matchup/League Facts

  • Heading into Week 16, the Dolphins rank T31st in the NFL in Q2 win percentage (14.3) this season.
  • Heading into Week 16, the Dolphins rank 30th in the NFL in forced fumbles (7) this season.
  • Heading into Week 16, the 49ers rank 32nd in the NFL in total punt yards (1796) this season.
  • Heading into Week 16, the 49ers rank T1st in the NFL in Q1 win percentage (71.4) this season.

Miami Dolphins vs San Francisco 49ers Prediction

The San Francisco 49ers just aren’t the team they’ve been in years past, and they’ve been even worse on the road, where they’ve lost 4 of 6 tries. The Dolphins have always played their best ball at home under coach Mike McDaniel, and that includes wins in their last three tries. With two underachieving teams that likely aren’t going to make the playoffs, I have to give the edge to home field. The Dolphins are the most comfortable under the sun, and we’ve seen the 49ers score 17 or fewer points in 4 of their last 5 games. Give me the home team in this near pick ’em spot.

Randy Chambers's Free Pick: Miami Dolphins -1

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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