Minnesota Vikings vs Indianapolis Colts Prediction 10/25/26 NFL Picks Today

The Indianapolis Colts and the Minnesota Vikings meet Sunday in NFL action from US Bank Stadium in Minneapolis. Here’s a Vikings vs Colts prediction. We will look at this from a betting perspective and determine the best Vikings vs Colts pick.

Indianapolis Colts Betting Preview

The Colts have been a mixed bag for most of the year, and they’ve been mired in fighting off the .500 mark in the record column. Indianapolis started with consecutive losses to the Baltimore Ravens and Kansas City Chiefs, then beat the Houston Texans and Washington Commanders. After a loss to the Steelers Indy was sitting at 2-3 through five games.

In last Sunday’s matchup with the Tennessee Titans, the Colts did a bit of scoring in the second quarter and headed into the locker room with a 13-0 lead. Indy gave up 20 unanswered points from there though, and eventually lost a tough one 26-20. QB Daniel Jones was 22-of-42 for 269 yards, one TD and two picks. Johnathan Taylor had 94 rush yards and a score.

Minnesota Vikings Betting Preview

Over on the Vikings’ side, they rolled into their (pretty early) bye week on a great run. Minnesota opened up the season with five straight victories, taking out the rival Green Bay Packers and Chicago Bears in the first two. Next came three more wins over the Tampa Bay Buccaneers, Miami Dolphins and New Orleans Saints for that perfect 5-0 run thus far.

Back on October 11 versus the Saints, the Vikings had a couple of field goals in the first half on the way to a 7-6 halftime deficit. Minnesota added a couple more touchdowns and a field goal after that on the way to a 23-13 win. QB Kyler Murray was 24-of-30 for 229 yards and a TD. Aaron Jones led the rush in the victory with 25 carries for 113 yards and a score.

Why the Minnesota Vikings will win

• The Vikings have won each of their last 10 games.
• The Colts have lost each of their last nine games against opponents on a winning streak.
• The Vikings have covered the spread in nine of their last 10 October games as favorites against AFC opponents.
• The Colts have failed to cover the spread in eight of their last nine games as underdogs against NFC opponents.
• The Vikings have won the first quarter in each of their last five games following a road win.
• The Vikings have scored the first touchdown in four of their last five games following a road win.
• The Vikings have won the first half in five of their last six games against teams that held a losing record.

Why the Indianapolis Colts will win

• The Colts have won three of their last four Week 7 games as road underdogs.
• The Vikings have lost four of their last five games without Andrew Van Ginkel.
• The Colts have covered the spread in each of their last four games without Jonathan Taylor.
• The Vikings have failed to cover the spread in 10 of their last 12 October games at U.S. Bank Stadium.
• The Colts have won the first quarter in four of their last five games as underdogs against NFC North opponents.
• The Colts have scored the first touchdown in each of their last eight games following a loss.
• The Colts have won the first half in seven of their last eight games against the Vikings.

Total Points Facts

• Each of the Vikings’ last eight games as favorites without Carson Wentz have gone UNDER the total points line.
• Each of the Colts’ last six games as road underdogs following a home loss have gone OVER the total points line.
• Five of the last six Sunday games at U.S. Bank Stadium have gone UNDER the total points line.

Minnesota Vikings Player Prop Facts

• Jordan Mason has recorded 13+ rushing yards in each of his last 15 regular season home appearances.
• Jordan Mason has scored at least one touchdown in four of his last five appearances with the Vikings as home favorites.
• Justin Jefferson has recorded 79+ receiving yards in each of his last 10 October appearances with the Vikings as favorites.
• Kyler Murray has recorded 220+ passing yards in each of his seven previous appearances with his team as a home favorite against AFC opponents.
• Jordan Mason has recorded 31+ rushing and receiving yards in each of his last nine appearances at U.S. Bank Stadium.
• Aaron Jones has scored the first touchdown in three of his four previous Week 7 home appearances.
• Kyler Murray has recorded 21+ completions in each of his last six appearances in day games against AFC opponents.
• Heading into Week 7, Byron Murphy ranks T1st in the NFL in interceptions (3) this season.

Indianapolis Colts Player Prop Facts

• Jonathan Taylor has scored at least one touchdown in four of the Colts’ last five games against NFC opponents.
• Daniel Jones has recorded 257+ passing yards in each of his last four October appearances with his team as a road underdog.
• Jonathan Taylor has recorded 121+ rushing and receiving yards in three of the Colts’ last four games following a loss.
• Daniel Jones has recorded 15+ rushing yards in each of his last seven appearances against NFC North opponents.
• Keenan Allen has recorded 53+ receiving yards in eight of his nine previous road appearances against NFC North opponents.
• Daniel Jones has recorded 21+ completions in eight of his nine previous appearances with his team as an underdog against NFC North opponents.
• Heading into Week 7, Spencer Shrader ranks 1st in the NFL in made field goals (18) this season.

Matchup/League Facts

• Vikings – three different players have recorded 90+ receiving yards in a game this season – equal-most in the NFL, heading into Week 7.
• Heading into Week 7, the Vikings rank 1st in the NFL in points allowed per game (12.8) this season.
• Heading into Week 7, the Colts rank 32nd in the NFL in turnover differential (-8) this season.
• Heading into Week 7, the Colts have lost the third quarter in each of their last two games – equal-longest active streak in the league.

Vikings vs Colts Prediction

I’ll lean toward the Vikings. Minnesota held the Saints in check during their last outing, giving up just nine first downs and a 2-of-10 success rate on third-down tries alongside 142 total yards. Offensively the Vikings came up with 364 yards and 18 first downs in the 10-point victory. Minnesota is on a nice roll right now but they’re not necessarily blowing teams out to get their wins. Three of the five have come by one score.

As for Indianapolis, they took a weird loss to Tennessee last weekend despite giving up only 11 first downs, 21:26 in time of possession and 186 total yards on defense. The three turnovers torpedoed an otherwise solid offensive day for the Colts on 24 first downs and 399 yards. This matchup will be even tougher.