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Cardinals vs Mariners Prediction 4/26/26 MLB Picks Today

Seattle Mariners (13-15) vs. St. Louis Cardinals (14-12)
April 26, 2026 2:15 pm EDT
The Line: St. Louis Cardinals 123 / Seattle Mariners -149; Over/Under: 8
(Get latest betting odds)

The Seattle Mariners and St. Louis Cardinals meet Sunday in MLB action at Busch Stadium. Here’s a Cardinals vs. Mariners Prediction. This article will include a Cardinals vs. Mariners Pick.

Seattle Mariners Betting Preview

The Seattle Mariners are 13-15 on the year and play the Royals and Twins next. The Seattle Mariners are batting. 233 on the season, have a .326 OBP, and have a .376 slugging percentage. The Seattle Mariners pitching staff has a 3.57 ERA and a 1.23 WHIP. Randy Arozarena leads the Seattle Mariners with 29 hits and 11 RBI while Cole Young and Julio Rodriguez have combined for 52 hits and 23 RBI.

Emerson Hancock gets the ball for the Seattle Mariners, and he is 2-1 with a 2.83 ERA and 28 strikeouts this season. This will be Hancock’s second career game against the St. Louis Cardinals.

St. Louis Cardinals Betting Preview

The St. Louis Cardinals are 14-12 on the year and play the Pirates and Dodgers next. The St. Louis Cardinals are batting .236 on the season and have a .325 OBP, and a .388 slugging percentage. The St. Louis Cardinals pitching staff has a 4.94 ERA and a 1.45 WHIP. Jordan Walker leads the St. Louis Cardinals with 27 hits and 16 RBI while Alec Burleson and JJ Wetherholt have combined for 48 hits and 29 RBI.

Michael McGreevy gets the ball for the St. Louis Cardinals, and he is 1-2 with a 3.29 ERA and 15 strikeouts this season. This will be McGreevy’s second career game against the Seattle Mariners.

Why the St. Louis Cardinals will win

  • The Mariners have lost seven of their last eight games as road favorites after playing the previous day.
  • The Cardinals have won four of their last five games as underdogs against AL West opponents following a home loss.
  • The Mariners have failed to cover the run line in seven of their last eight games as road favorites.
  • The Cardinals have covered the run line in six of their last seven games against American League opponents.
  • The Mariners have trailed after 3 innings in four of their last five day games against National League opponents that held a winning record.
  • The Mariners have trailed after 5 innings in seven of their last eight games as road favorites.

Why the Seattle Mariners will win

  • The Mariners have won each of their last six games against the Cardinals.
  • The Cardinals have lost seven of their last eight day games against American League opponents following a loss.
  • The Cardinals have failed to cover the run line in each of their last six day games against American League opponents following a home loss.
  • The Mariners have covered the run line in each of their last six Sunday day road games against National League opponents.
  • The Mariners have led after 3 innings in three of their last four games as road favorites against NL Central opponents.

Total Runs Facts

  • Eight of the Cardinals’ last nine games as underdogs against American League opponents have gone OVER the total runs line.
  • Five of the Mariners’ last six games as road favorites have gone UNDER the total runs line.
  • The ‘Inning 1 OVER 0.5 runs’ market has been hit in each of the Mariners’ last six day games.
  • The ‘Inning 1 OVER 0.5 runs’ market has been hit in each of the last five day games between the Mariners and Cardinals.

St. Louis Cardinals Player Prop Facts

  • Masyn Winn has recorded at least one hit in each of his last 10 appearances.
  • Ramon Urias has hit a home run in four of his last eight home appearances against AL West opponents.

Seattle Mariners Player Prop Facts

  • Cal Raleigh has hit at least one home run in three of his last four appearances in day games against NL Central teams that held a winning record.
  • Randy Arozarena has recorded at least one hit in each of his last 11 appearances against the Cardinals.

Cardinals vs Mariners Prediction

The Cardinals have been outplayed in this series and the Mariners have the pitching edge in this spot. While McGreevy has been solid, Hancock has a 2.83 ERA, 0.87 WHIP and 28 strikeouts in 28.2 innings. Hancock looks like he could be an all-star this year. The price is reasonable and this has simply been a rough week for the Cardinals overall. Give me the Mariners to stay hot and win their fourth straight game.

Randy Chambers's Free Pick: Seattle Mariners -149

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Randy Chambers

Randy has covered sports betting since 2014 and writes about everything from NFL to WNBA. Follow Randy Chambers on Twitter.

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