Houston Astros vs Colorado Rockies Prediction 4/15/26 MLB Picks Today

The Colorado Rockies and the Houston Astros meet Wednesday in MLB action from Daikin Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Colorado Rockies vs. Houston Astros prediction.

Starting Pitching Matchup

The Colorado Rockies will send out Jose Quintana for the start here and Quintana is 0-0 with a 4.15 ERA and 2 strikeouts this season. In his last five starts against the Astros, Quintana is 2-1 with a 2.93 ERA and 26 strikeouts. Spencer Arrighetti will start for the Astros here and was 1-5 with a 5.35 ERA and 31 strikeouts last season. This will be Arrighetti’s second career start against the Rockies.

Colorado Rockies Recap

The Colorado Rockies come into this game looking to shake off their series-opening 7-6 loss to Houston on Tuesday to slip to 6-11 this season. After this series, the Rockies will head home for a series against the Los Angeles Dodgers.

Rockies Drop 5th Straight

TJ Rumfield has 17 hits with a double, a triple, 2 home runs and 8 RBIs while Ezequiel Tovar has 17 hits with 7 doubles, a home run and 6 RBIs. Hunter Goodman’s added 15 hits with a double, 4 home runs and 7 RBIs and Jordan Beck has 6 RBIs as well on the year. Troy Johnston has 14 hits with 3 doubles, 2 home runs and 7 RBIs. Willi Castro also has 11 hits with 3 doubles, a home run and 7 RBIs.

Houston Astros Recap

The Houston Astros come into this game fresh off of their win over the Rockies to start the series and improve to 7-11 on the year. After this series, the Astros will take on the St. Louis Cardinals at home.

Astros Snap Eight-Game Slide

Yordan Alvarez has 19 hits with 5 doubles, 6 home runs and 16 RBIs while Christian Walker has 20 hits with 6 doubles, 4 home runs and 15 RBIs on the year. Jose Altuve’s chipped in 19 hits with 5 doubles, 2 home runs and 6 RBIs and Carlos Correa has 17 hits with 3 doubles, a home run and 9 RBIs. Cam Smith also has 18 hits with 4 doubles, 3 home runs and 9 RBIs. Yainer Diaz also has 11 hits with a double, a home run and 9 RBIs.

Colorado Rockies @ Houston Astros Betting Trends: April 15, 2026

• Probable Starting Pitcher: Spencer Arrighetti      Record this season: –      ERA: –
• Home Record: –
• Last 5 against Rockies: 1-0

Why the Houston Astros will win

• The Astros have won each of their last 15 games against the Rockies following a home win.
• The Rockies have lost each of their last 12 road games against teams that held a losing record.
• The Rockies have failed to cover the run line in each of their last eight Wednesday night games against American League opponents.
• The Astros have covered the run line in each of their last five night games against National League opponents following a win.
• The Rockies have trailed after 5 innings in each of their last 12 road games against opponents that held a losing record.
• The Astros have won the first inning in three of their last four home games.
• The Rockies have trailed after 3 innings in seven of their last eight road games against opponents that held a losing record.

• Probable Starting Pitcher: Jose Quintana      Record this season: 0-0      ERA: 4.15
• Road Record: 0-0
• Last 5 against Astros: 1-0

Why the Colorado Rockies will win

• The Astros have lost five of their last six games as favorites.
• The Rockies have won four of their last five games as underdogs against American League opponents.
• The Astros have failed to cover the run line in each of their last six games as favorites.
• The Rockies have covered the run line in seven of their last eight games against the Astros.
• The Astros have lost the first inning in each of their last six games.
• The Rockies have led after 3 innings in four of their last five road games against AL West opponents that held a losing record.
• The Astros have trailed after 5 innings in five of their last six games as favorites.

Total Runs Facts

• Each of the Astros’ last six home games have gone OVER the total runs line.
• Four of the Rockies’ last five games have gone OVER the total runs line.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Astros’ last six games.
• The ‘Inning 1 OVER 0.5 runs’ market has hit in each of the Rockies’ last seven Wednesday night games against AL West opponents.

Houston Astros Player Prop Facts

• Yainer Diaz has hit a home run in three of his last four home appearances against NL opponents that held a losing record.
• Christian Walker has recorded at least one hit in each of his last 25 appearances against the Rockies after playing the previous day.
• Yordan Alvarez ranks 2nd amongst qualified players for On Base Percentage (.475) this season.

Colorado Rockies Player Prop Facts

• Jose Quintana has recorded a win in five of his last six road appearances against opponents that held a losing record.
• Hunter Goodman has hit at least one home run in each of the Rockies’ last two games against the Astros.
• Willi Castro has recorded at least one hit in each of his last nine appearances against the Astros after playing the previous day.
• Jose Quintana has recorded three or more strikeouts in each of his 13 previous Wednesday appearances against AL teams that held a losing record.
• Mickey Moniak ranks T8th in the league in Home Runs (5) this season.

Matchup/League Facts

• The Astros rank 1st in the league for runs scored this season (102).
• The Astros rank T1st in the league for hits this season (169).
• The Rockies rank 29th in the league for strikeouts against this season (174).
• The Rockies rank 29th in the league for strikeouts this season (122).

Colorado Rockies vs. Houston Astros Prediction

I’m on the Rockies in this one. I get the case to be made for either side in this game, but I’m not laying this price with Houston off of one win and with Arrighetti returning to the bump after he wasn’t good last season. Quintana’s a solid veteran for this Rockies rotation, and I think he does enough to get his team the W so give me Colorado here.