St. Louis Cardinals vs Chicago Cubs Prediction 7/28/26 MLB Picks Today

The Chicago Cubs and the St. Louis Cardinals meet Tuesday in MLB action from Busch Stadium. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. St. Louis Cardinals prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Colin Rea here and Rea is 7-7 with a 4.85 ERA and 81 strikeouts this season. The St. Louis Cardinals did not have a starting pitcher announced at the time that this article was posted.

Chicago Cubs Recap

The Chicago Cubs come into this game looking to add on to their 7-3 win over the Cardinals from Monday’s opener to improve to 60-46 this season. After this series, the Cubs will head home for a series against the New York Yankees.

Cubs Win 6 Of Last 9

Ian Happ has 82 hits with 18 doubles and 18 home runs and 45 RBIs while Alex Bregman has 98 hits with 17 doubles, a triple, 11 home runs and 46 RBIs. Nico Hoerner’s added 106 hits with 23 doubles, 5 home runs and 48 RBIs and Moises Ballesteros has 36 hits with 6 home runs and 23 RBIs. Pete Crow-Armstrong’s also added 114 hits with 19 doubles, 6 triples, 23 home runs and 60 RBIs as well on the year. Carson Kelly has also contributed 64 hits with 10 doubles, 6 home runs and 36 RBIs. Michael Busch has 96 hits wtih 18 doubles, 13 home runs and 56 RBIs. Dansby Swanson also has 77 hits with 16 home runs and 61 RBIs.

St. Louis Cardinals Recap

The St. Louis Cardinals come into this game looking to shake off their loss at the hands of the Cubs from Monday’s opening game to fall to 53-53 this season. After this series, the Cardinals will take on the Toronto Blue Jays on the road.

Cardinals Drop 7 Of Last 9

Jordan Walker has 114 hits, 23 doubles, 22 home runs and 77 RBIs while Alec Burleson has 116 hits with 26 doubles, 15 home runs and 71 RBIs. JJ Wetherholt has 100 hits with 15 home runs and 40 RBIs while Ivan Herrera has 95 hits with 15 doubles, 12 home runs and 44 RBIs. Nolan Gorman has 39 hits with 7 home runs and 26 RBIs this season. Masyn Winn’s added 85 hits with 12 doubles and 43 RBIs and Nathan Church has 59 hits with 8 home runs and 30 RBIs this season.

The Chicago Cubs @ St. Louis Cardinals Betting Trends: July 28, 2026

• Probable Starting Pitcher: Michael McGreevy      Record this season: 4-8      ERA: 3.07
• Home Record: 2-3
• Last 5 against Cubs: 1-1

Why the St. Louis Cardinals will win

• The underdogs have won five of the Cardinals’ last six games.
• The Cubs have lost each of their last three games as road favorites against the Cardinals following a win.
• The Cardinals have covered the run line in eight of their last nine games as underdogs against National League opponents following a loss.
• The Cubs have failed to cover the run line in each of their last five night games against the Cardinals following a win.
• The Cardinals have won the first inning in three of their last four home games against opponents that held a winning record.
• The Cardinals have led after 5 innings in four of their last five night games against National League opponents.

• Probable Starting Pitcher: Colin Rea      Record this season: 7-7      ERA: 4.85
• Road Record: 4-4
• Last 5 against Cardinals: 3-0

Why the Chicago Cubs will win

• The Cardinals have lost each of their last four games against teams that held a winning record.
• The Cubs have won each of their last four night games against NL Central opponents.
• The Cubs have covered the run line in each of their last seven road games following a win.
• The Cardinals have failed to cover the run line in five of their last six home games.
• The Cubs have won the first inning in seven of their last nine games as favorites.
• The Cardinals have trailed after 5 innings in five of their last six home games against opponents that held a winning record.
• The Cubs have led after 3 innings in each of their last five Tuesday games.

Total Runs Facts

• Each of the Cubs’ last four road games after playing the previous day have gone OVER the total runs line.
• Six of the Cardinals’ last seven night games after playing the previous day have gone UNDER the total runs line.
• There has been no run scored during the first inning in each of the Cardinals’ last eight Tuesday night games against National League opponents.
• There has been at least one run scored in the first inning in eight of the Cubs’ last nine games as favorites.

St. Louis Cardinals Player Prop Facts

• Jimmy Crooks has hit a home run in two of his last three appearances with the Cardinals as underdogs against NL opponents.
• JJ Wetherholt has recorded at least one hit in each of the Cardinals’ last seven games against the Cubs.
• Michael McGreevy has recorded a win in four of his last five appearances with the Cardinals as home underdogs against NL opponents.
• Michael McGreevy has recorded four or more strikeouts in five of his last six appearances with the Cardinals as underdogs against NL opponents.
• Alec Burleson ranks 8th in the league in Hits (116) this season.

Chicago Cubs Player Prop Facts

• Alex Bregman has hit a home run in each of the Cubs’ last two road games against the Cardinals.
• Colin Rea has recorded a win in each of his last three appearances against the Cardinals.
• Colin Rea has recorded four or more strikeouts in each of his last six appearances with the Cubs as favorites against NL Central opponents.
• Pedro Ramirez has recorded at least one hit in each of his last seven appearances.
• Pete Crow-Armstrong ranks T4th in the league in Steals (26) this season.

Matchup/League Facts

• The Cardinals rank 28th in the league for doubles this season (143).
• The Cardinals rank 28th in the league for doubles this season (143).
• The Cubs rank 1st in the league for walks this season (460).
• The Cubs rank 1st in the league for walks this season (460).

Chicago Cubs vs. St. Louis Cardinals Prediction

I’m on the Cardinals in this one. I just don’t trust Colin Rea in this Cubs rotation, and I think that this is just a bad spot for Chicago with St. Louis desperate for a win after falling short on Monday. All in all, I look for St. Louis to bounce back and stop the bleeding a bit with a win here. Give me the Cards.