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Tigers vs Cubs Prediction 6/6/25 MLB Picks Today

Chicago Cubs (39-23) vs. Detroit Tigers (41-23)
June 6, 2025 7:10 pm EDT
The Line: Detroit Tigers -198 / Chicago Cubs +164; Over/Under: 7
(Get latest betting odds)

The Chicago Cubs and the Detroit Tigers meet Friday in MLB action from Comerica Park. We will look at this from a betting perspective and determine the best bets for this game. Here’s a Chicago Cubs vs. Detroit Tigers prediction.

Starting Pitching Matchup

The Chicago Cubs will send out Ben Brown for the start here, and Brown is 3-3 with a 5.72 ERA and 71 strikeouts this season. This will be Brown’s first career start against the Tigers. The Detroit Tigers will start Tarik Skubal here, and Skubal is 5-2 with a 2.26 ERA and 99 strikeouts this season. In his career, Skubal is 0-1 with a 6.00 ERA and 12 strikeouts against the Cubs.


Chicago Cubs Recap

The Chicago Cubs come into this game looking to build on their 7-1 win over the Washington Nationals to close out their most recent series to improve to 39-23 on the year. After this series, the Cubs will head on the road again for a series against the Philadelphia Phillies.

Cubs Win 8 Of Their Last 10

Ian Happ has 57 hits with 13 doubles, 4 home runs, and 25 RBIs. Kyle Tucker has 65 hits, including 11 doubles, 4 triples, 12 home runs, and 39 RBIs, while Seiya Suzuki also has 62 hits with 18 doubles and 14 home runs and 53 RBIs of his own. Miguel Amaya added 9 doubles and 25 RBIs, and Pete Crow-Armstrong also has contributed 67 hits, 15 doubles, 3 triples, 16 home runs, and 53 RBIs as well this season. Dansby Swanson has added 11 home runs and 34 RBIs, while also having the unfortunate distinction of leading the Cubs with 72 strikeouts so far this season. Crow-Armstrong also has a team-high 21 stolen bases, while Nico Hoerner has 13 stolen bases this season. Tucker’s also added 16 stolen bases, while Michael Busch has also chipped in 9 home runs and 36 RBIs this season.

Why the Chicago Cubs will win

  • The Cubs have won each of their last five games as road underdogs against American League opponents following a win.
  • The Tigers have lost each of their last seven Friday games against National League opponents that held a winning record.
  • The Cubs have covered the run line in nine of their last 10 road games against American League opponents after playing the previous day.
  • The Tigers have failed to cover the run line each of their last five night games against NL Central opponents that held a winning record.

Chicago Cubs Player Prop Facts

  • Kyle Tucker has hit a home run in each of his last three road appearances against the Tigers.
  • Seiya Suzuki has recorded at least one RBI in nine of the Cubs’ last 10 games against AL opponents.
  • Dansby Swanson has scored at least one run in each of his last eight appearances against the Tigers.
  • Justin Turner has recorded at least one hit in each of his last 12 appearances in night games against AL teams that held a winning record.
  • Justin Turner has recorded at least one Single in each of his last eight road appearances against AL opponents.
  • Pete Crow-Armstrong ranks T2nd in the league in Steals (21) this season.

Detroit Tigers Recap

The Detroit Tigers come into this game looking to bounce back from a 3-2 loss at the hands of the Chicago White Sox last time out to fall to 41-23 on the year. After this series, the Tigers will take on the Baltimore Orioles in a road series.

Tigers Trying To Find Some Consistency

Spencer Torkelson has 49 hits along with a .227 batting average, including a team-high 14 home runs, 14 doubles, and 42 RBIs. Kerry Carpenter also has 13 home runs and 27 RBIs, while Riley Greene has 67 hits with 14 doubles, 13 home runs and 42 RBIs, but also has a team-high 79 strikeouts this season. Dillon Dingler has 6 home runs and 27 RBIs, and Zack McKinstry’s added 10 doubles, 4 triples, 3 home runs, and 19 RBIs of his own, along with 51 hits as well this season. Javier Baez has added 50 hits and 10 doubles as well as 6 home runs and 30 RBIs this season.

Why the Detroit Tigers will win

  • The Tigers have won each of their last 10 games as favorites following a road loss.
  • The Cubs have lost each of their last four games against the Tigers following a road win.
  • The Cubs have failed to cover the run line in seven of their last eight night games against AL Central opponents following a win.
  • The Tigers have covered the run line in seven of their last eight home games against National League opponents following a loss.

Detroit Tigers Player Prop Facts

  • Kerry Carpenter has hit a home run in each of the Tigers’ last two games as favorites against NL Central opponents.
  • Kerry Carpenter has recorded at least one RBI in five of his six previous home appearances against NL Central opponents that held a winning record.
  • Gleyber Torres has scored a run in each of the Tigers’ last five home games.
  • Tarik Skubal has recorded eight or more strikeouts in each of his last five appearances against NL Central opponents.
  • Colt Keith has recorded a Double in each of his last four appearances with the Tigers as home favorites.
  • Wenceel Perez has recorded at least one hit in each of his last 11 appearances in night games.
  • Gleyber Torres has recorded at least one Single in each of his last seven appearances against the Cubs.
  • Tarik Skubal has recorded a win in each of his last four appearances at Comerica Park against opponents that held a winning record.
  • Tarik Skubal ranks 3rd in the league for total Strikeouts (99) this season.

Total Runs Facts

  • Nine of the Cubs’ last 10 games against American League opponents have gone OVER the total runs line.
  • Each of the Tigers’ last five home games against NL Central opponents have gone OVER the total runs line.

Chicago Cubs vs. Detroit Tigers Prediction

I’m on the Tigers here. Tarik Skubal is obviously a massive edge for the Tigers in this matchup opposite Ben Brown, but the edge that the Cubs have is in relief in the bullpen, and I think that Tarik Skubal can eat up enough innings in this game to where the Cubs have as little time with that advantage as possible. The Cubs haven’t been as strong against lefties as they were to start the year, and I think Detroit bounces back at home in this one. Give me the Tigers in a win at home behind their ace.

Chris Ruffolo's Free Pick: Detroit Tigers -198

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Chris Ruffolo

Chris joined the Sports Chat Place team in August 2016 and has a proven system that combines multiple analytical and situational statistics and trends to give out thousands of winning picks over the last three years with winning records across all of the top leagues, Follow Chris Ruffolo on Twitter @ruffthepickdawg

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