Bulls vs Pistons Prediction 10/22/25 NBA Picks Today

The Detroit Pistons and Chicago Bulls meet Wednesday in NBA action at the United Center. Here’s a Bulls vs Pistons Prediction. This article will include a Bulls vs Pistons Pick.

Detroit Pistons Betting Preview

The Detroit Pistons won 44 games last season and ended their playoff drought. The Pistons now look to make the postseason in back-to-back seasons for the first time since the 2008-09 season.

The Pistons have a young, intriguing core that includes Cade Cunningham, Ausar Thompson, and Jalen Duren. A full season of Isaiah Stewart will help, and the addition of Duncan Robinson opens up the court. I’m not sure about the Pistons depth and I always question Tobias Harris’ consistency, but this is a group that has an identity and should be hungrier than ever after tasting playoff success. The Pistons are one of those teams that can move up in the wide open east. Keep an eye on Detroit basketball. 

Chicago Bulls Betting Preview

The Chicago Bulls won 39 games last season and haven’t made the playoffs since the 2021-22 season. The Bulls haven’t won a playoff series since the 2014-15 season.

The Bulls have an intriguing back court in Josh Giddey and Coby White that plays an exciting brand of basketball. Nikola Vucevic is the grizzly productive center down low, and Isaac Okoro has a chance to expand his game coming over from Cleveland. Matas Buzelis showed flashes as a rookie and has high upside after just turning 21 years old. It’s often fair to question what direction the Bulls are heading, and I’m still not sure if this roster is good enough to compete for a playoff spot. Still, the Bulls had moments last season and this is a fairly young roster with only two players 30 years old or older.

Why the Chicago Bulls will win

• The Pistons have lost each of their last four games as favorites.
• The underdogs have won four of the Pistons’ last five games.
• The Pistons have failed to cover the spread in each of their last four games as favorites.
• The Bulls have covered the spread in five of their last six games as home underdogs.

Why the Detroit Pistons will win

• The Bulls have lost seven of their last eight home openers.
• The favorites have won 13 of the Pistons’ last 14 games at United Center.
• The favorites have covered the spread in 11 of the Pistons’ last 12 games at United Center.
• The Bulls have failed to cover the spread in seven of their last eight games against Central Division opponents.

Total Points Facts

• Eight of the Bulls’ last nine games as underdogs have gone OVER the total points line.
• Each of the Pistons’ last four games against Central Division opponents have gone OVER the total points line.

Detroit Pistons Player Facts

• Cade Cunningham has recorded 7+ assists in four consecutive appearances – equal-longest active streak of any player in the league.

Bulls vs Pistons Injury Report

The Pistons will be without Jaden Ivey, while Marcus Sasser is doubtful with a hip issue.

The Bulls will be without Zach Collins and Coby White.

Bulls vs Pistons Prediction

The Pistons comfortably beat the Bulls in the last 4 meetings, and they come back this season as a better team. The Bulls remain without an identity, and they’re down one of their best players in White. If the Pistons are going to build on last year’s success and push for a top seed in the east, these are games they take advantage of early. Last year’s seeding showed us that every game counts. This line is soft. Give me the Pistons.