Cleveland Cavaliers (0-0) vs. NY Knicks (0-0)
October 22, 2025 7:00 pm EDT
The Line: NY Knicks +1; Over/Under: 228.5
(Get latest betting odds)
The Cleveland Cavaliers and New York Knicks meet Wednesday in NBA action at the Madison Square Garden. Here’s a Knicks vs Cavaliers Prediction. This article will include a Knicks vs Cavaliers Pick.
Cleveland Cavaliers Betting Preview
The Cleveland Cavaliers hope they can take that next step after 64 wins and a trip to the second round of the playoffs. It was the second most wins in franchise history.
The Cavs bring back the stacked roster they had last season that includes Darius Garland, Donovan Mitchell, Evan Mobley, and Jarrett Allen. The Cavs did lose Ty Jerome, but they get a full season of De’Andre Hunter and added Lonzo Ball. The Cavaliers showed they’re one of the best teams in the league, and this core is good enough to come out of the East. It’s just a question of this roster having enough difference makers to close the deal on a ring. In the playoffs, who are going to come with Mitchell and elevate their game to bring a second title to the franchise. Time will tell.
New York Knicks Betting Preview
The New York Knicks won 51 games last season and made the conference finals. The Knicks now begin the Mike Brown era.
The Knicks are rolling out a similar roster as well with Jalen Brunson, Mikal Bridges, OG Anunoby, and KAT leading the way. Josh Hart is the main guy off the bench, and the addition of Jordan Clarkson adds much needed scoring. A full season of Mitchell Robinson would go a long way, especially with the lack of depth in the Knicks front court. It will be interesting to see how the Knicks starting five are managed, as Tom Thibodeau played his guys into the ground and they were dead come playoff time. The Knicks remain one of the most talented teams in the East.
Why the New York Knicks will win
- The Cavaliers have lost four of their last five games as favorites.
- The underdogs have won each of the Cavaliers’ last three games at Madison Square Garden.
- The Cavaliers have failed to cover the spread in four of their last five games.
- The home team has covered the spread in each of the Knicks’ last three games.
Why the Cleveland Cavaliers will win
- The Cavaliers have won each of their last seven games against Atlantic Division opponents.
- The Knicks have lost each of their last seven season openers as underdogs.
- The Knicks have failed to cover the spread in each of their last six home openers as underdogs.
- The road team has covered the spread in seven of the Cavaliers’ last eight games.
Total Points Facts
- Each of the Knicks’ last seven home games against the Cavaliers have gone UNDER the total points line.
- Each of the Cavaliers’ last six night games at Madison Square Garden have gone UNDER the total points line.
Knicks vs Cavaliers Injury Report
The Cavs will be without Darius Garland and Max Strus. De’Andre Hunter is questionable with a knee injury.
The Knicks will be without Josh Hart and Mitchell Robinson. Karl-Anthony Towns is questionable with a quad injury.
Knicks vs Cavaliers Prediction
The Cavaliers have won the last four games against the Knicks, and that probably gives them the edge in this meeting. However, there are a lot of injuries to key players on both sides, so who knows what to expect. This is a spot you check the injury report before betting. At the time of this writing, I’ll lean Knicks at home. I have to see KAT suit up though. MSG should be buzzing for this one, and the Cavs are down two rotation players already, on top of losing Jerome. The Knicks are in better shape roster wise entering this spot. I’ll lean Knicks.
