Pitt beat Boston College last week and now looks to win back-to-back games for the first time this season. Duke is coming off losses to North Carolina and Virginia, but 5 of its 6 wins this season have come at home. Here’s a Pittsburgh vs Duke football Prediction. 

Pittsburgh vs Duke Odds

Duke is a 6.5-point favorite and the over / under is set at 42.5 points. This is now the fourth time in the last five years we’ve seen a single-digit favorite between Pitt and Duke. 

Pittsburgh vs Duke Injuries

Pitt tight end Gavin Bartholomew is doubtful with a foot injury. Duke quarterback Henry Belin IV is questionable with an upper body injury. Grayson Loftis should get the nod at QB for Duke this weekend. 

Pittsburgh vs Duke Recent Meeting

Pitt upset Duke last year 28-26 despite being 6.5-point underdogs. Pitt has won each of the last 7 meetings against Duke and has covered 6 of the last 9 meetings overall. Duke hasn’t beaten Pitt since that 2014 shootout when Anthony Boone was quarterback of the Blue Devils. 

Duke Blue Devils Team Facts

• The home team has won each of Duke’s last six games.
• Duke has failed to cover the spread in eight of its last nine November games as a favorite against non-AP-ranked teams.
• Seven of Duke’s last eight November games as a favorite against non-AP-ranked teams have gone OVER the total points line.

Pittsburgh Panthers Team Facts

• Pittsburgh has won each of its last seven games against Duke.
• Pittsburgh has covered the spread in each of its last four games at Brooks Field at Wallace Wade Stadium.
• Pittsburgh has won the first half in each of its last three games against conference opponents at Brooks Field at Wallace Wade Stadium.
• Four of Pittsburgh’s last five November games against non-AP-ranked teams have gone OVER the total points line.

Randy’s Free Pick

Duke should be the obvious favorites here, as Pitt has serious offensive issue and hasn’t been able to string together success. However, Duke hasn’t been the same team that started 4-0 as they’ve lost 4 of their last 5 games and have question marks at quarterback. Pitt has owned Duke in past meetings, and that includes in the underdog role. I’ll take a stab with Pittsburgh and the points.